一、报告时间
2025年11月5日（星期三）上午9:00
二、报告地点
明德区行德楼A102（广东省粤北食药资源利用与保护重点实验室学术报告厅）
三、报告主题
（一）主讲嘉宾：罗格斯大学 黄庆荣 教授
报告题目：Bioefficacy, biotransformation, and bioavailability enhancement of citrus polymethoxyflavones
摘要：Polymethoxyflavones (PMFs) are a unique group of flavonoids that abundantly exist in the citrus peels. Multiple health benefits including anti-inflammation, anti-cancer, anti-diabetes and anti-obesity properties have been reported for PMFs. Our previous cell and mouse studies demonstrated that PMFs could attenuate obesity through AMP-activated protein kinase (AMPK) signaling. In this talk, we will discuss the mechanism underlying the anti-obesity activities using high-fat diet (HFD) induced obese mice fed with PMFs. We found that PMFs could significantly increase fecal short chain fatty acids, decrease Proteobacteria prevalence and the ratio of Firmicutes to Bacteroidetes, and significantly and dynamically promote beneficial bacteria, such as Akkermansia spp. and Allobaculum spp. The pharmacokinetic study demonstrated that the oral bioavailability of PMFs can be improved by ~20% by encapsulation using nanoemulsions. For the key PMFs component nobiletin, the major metabolites included 3'-demethylnobiletin (3'DMN), 4'-demethylnobiletin (4'DMN), and 3',4'-didemethylnobiletin (3'4'DDMN). Other mono-demethylated-nobiletins (DMNs) were also detected in pharmacokinetic and bio-efficacy studies. However, because of the lack of standards, the demethylation positions were not previously identified. We have successfully developed an efficient synthetic method for 6DMN and 7DMN using microbes isolated from aged citrus peels. 6DMN was found to be more potent in suppressing lipogenesis than 7DMN.
多甲氧基黄酮（PMFs）是一类富含于柑橘皮中的独特黄酮类化合物，具有抗炎、抗癌、抗糖尿病及抗肥胖等多重健康效益。我们前期细胞及小鼠实验表明，PMFs可通过AMP激活蛋白激酶（AMPK）信号通路减轻肥胖。本研究通过高脂饮食诱导的肥胖小鼠模型，系统探讨了PMFs的抗肥胖机制。结果显示：PMFs显著增加粪便短链脂肪酸含量，降低变形菌门丰度及厚壁菌门/拟杆菌门比值，并动态促进Akkermansia spp.和Allobaculum spp.等有益菌增殖。药代动力学研究表明，纳米乳液封装技术可使PMFs口服生物利用度提升约20%。针对关键成分诺比列汀（nobiletin）的代谢分析发现，其主要代谢产物包括3'-脱甲基诺比列汀（3'DMN）、4'-脱甲基诺比列汀（4'DMN）及3',4'-双脱甲基诺比列汀（3'4'DDMN），但受限于标准品缺乏，此前未能明确脱甲基位点。本研究利用从陈年柑橘皮中分离的微生物，成功开发了6DMN和7DMN的高效合成方法。功能评价显示，6DMN抑制脂质生成的效力显著优于7DMN。这些发现为PMFs抗肥胖作用的精准调控及临床转化提供了新策略。
（二）主讲嘉宾：罗格斯大学 Michael Leonidas Chikindas 教授
报告题目：芽孢益生菌在禽类养殖中的应用及其多重健康效应
摘要：本报告系统阐述了芽孢益生菌在禽类养殖中的应用及其多重健康效应。芽孢杆菌（如枯草芽孢杆菌KATMIRA1933和解淀粉芽孢杆菌B-1895）因其耐高温、耐储存、强定殖能力等特点，成为替代抗生素的理想选择。研究表明，芽孢益生菌通过调节肠道菌群平衡、抑制致病菌（如金黄色葡萄球菌、沙门氏菌）生物膜形成、增强黏膜屏障功能及免疫调控等机制，显著提升家禽生长性能（增重、饲料效率）、蛋品质（重量、蛋壳厚度、孵化率）及繁殖能力（精子质量、产蛋量）。此外，其分泌的抗氧化物质（如超氧化物歧化酶、亚精胺）可减少氧化应激，延缓禽类衰老，降低肠道炎症风险。临床试验表明，益生菌组家禽器官发育正常，血液指标健康，且未出现病原菌耐药性问题。纳米乳液封装技术进一步提升了芽孢益生菌的口服生物利用度。研究证实，芽孢益生菌通过浓度依赖性方式改善肉品质与风味，为无抗养殖提供新策略。未来需深入探索其代谢调控网络及多菌株协同效应，推动家禽健康养殖的产业化应用。
四、主讲人简介
（一）Dr. Qingrong Huang is currently a Professor at the Department of Food Science, Rutgers, The State University of New Jersey. He founded the first food nanotechnology lab in the USA and devoted his professional career to Food Nanotechnology and Biopolymer research. His research areas include novel functional food, nanoencapsulation technology, biopolymer nanocomposite material, and biological nanotechnology. He is the 2017-2024 Clarivate Analytics Highly Cited Researcher in Agricultural Science and the most cited author of the American Journal of Agricultural Chemistry in 2017. He was elected Fellow of the Agricultural Chemistry Department of the American Chemical Society in 2016. He has published 411 refereed journal papers in renowned journals like the Journal of the American Chemical Society, Food Hydrocolloids, Journal of Agricultural and Food Chemistry, etc. He has also published 15 book chapters and two books, such as “Micro/Nano Encapsulation of Active Food Ingredients” and “Nanotechnology in the Food, Beverage, and Nutraceutical Industries”.
（二）Dr. Michael Leonidas Chikindas is a Professor in Microbiology, leading the Health Promoting Naturals Laboratory. He co-authored several patents, more than a hundred peer-reviewed papers and six book chapters. Dr. Chikindas developed and implemented a number of courses at Rutgers, including Food Microbiology (lectures and lab courses) and Beneficial Microbes in Food and Life. He is co-teaching the graduate-level course Food Biology Fundamentals. Dr. Chikindas is an applied microbiologist studying natural-derived antimicrobials and probiotics for use in human health, personal care, and agricultural applications. His external funding stems from private industries/organizations such as Bill & Melinda Gates Foundation and governmental agencies such as NIH, USDA, NSF, etc. He serves on Editorial Boards of Applied and Environmental Microbiology, Annals of Microbiology, Antibiotics, and Beneficial Microbes (Section Editor). Dr. Chikindas was a founder of Probiotics and Antimicrobial Proteins, the Springer Nature journal, and served as its Editor-in-Chief for twelve consecutive years. He served on the Editorial Boards of Letters in Applied Microbiology and the Journal of Applied Microbiology (also as the journal’s Senior Editor) for twenty five years. He is a member of the American Society for Microbiology and the Society for Applied Microbiology (UK).
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广东省粤北食药资源利用与保护重点实验室
2025年11月03日
